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Mus musculus
4 Downloadable Samples
Illumina Genome Analyzer IIx
Description
Using a mouse BMT model, we examined the in vivo effect of simultaneous expression of ASXL1-MT and SETBP1-D868N. All of the mice transplanted with BM cells expressing both ASXL1-MT and SETBP1-D868N died of acute leukemia after a short latency, while all of the mice transplanted with BM cells expressing either ASXL1-MT or SETBP1-D868N alone survived for 6 months after transplantation. To elucidate the mechanism for leukemogenesis induced by the combination of ASXL1-MT and SETBP1-D868N, we compared the expression profile of BM cells of AML mice induced by both ASXL1-MT and SETBP1-D868N with that of BM cells of MDS mice induced by ASXL1-MT.
Publication Title
No associated publication
Sample Metadata Fields
Specimen part, Cell line
View Samples- Mus musculus
- 6 Downloadable Samples
- NextSeq 500
Description
No description.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Specimen part, Cell line, Treatment
View Samples- Homo sapiens
- 1 Downloadable Sample
Description
Investigate epigenetic mechanisms contributing to stemness/pluripotency in lung cancers and potentially identify novel therapeutic targets in these malignancies.
Publication Title
No associated publication
Sample Metadata Fields
No sample metadata fields
View Samples- Mus musculus
- 9 Downloadable Samples
- Illumina Genome Analyzer IIx
Description
Ly6A/Sca-1 Fbxl10 Tg mice develop myeloid and B-cell leukemia with complete penetrance. (Ueda et al.,Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2, PMID 25872778)
Publication Title
No associated publication
Sample Metadata Fields
No sample metadata fields
View Samples- Mus musculus
- 8 Downloadable Samples
- Illumina Genome Analyzer IIx
Description
An activating mutation of ALK, ALK R1275Q was idenftified in neuroblastoma. ALK R1275Q knock-in/MYCN transgenic mice developed invasive and metastatic neuroblastoma with complete penetrance, coupled with decreased extracellular matrix/basement membrane components.
Publication Title
No associated publication
Sample Metadata Fields
No sample metadata fields
View Samples
DRP002819- Mus musculus
- 5 Downloadable Samples
- Illumina Genome Analyzer IIx
Description
An Immrtalized mouse embryonic fibroblast cell line (iMEF) was transduced with shRNA expression vectors and subjected for RNA-seq anaysis. Taf1c was knocked down by two different shRNAs. Enl and Mll were knocked down by single shRNA. RNAs were reverse-transcribed and subjected to deep sequencing along with the vector control sample (pLKO.1)
Publication Title
No associated publication
Sample Metadata Fields
Specimen part, Cell line
View Samples- Mus musculus
- 2 Downloadable Samples
- Illumina HiSeq 2500
Description
Transcriptome analysis of hematopoietic stem cells [HSC (LSK)] (Eed cKO (flox/+ ERT2Cre+) vs control (flox/+ ERT2Cre-), 1 month post-tamoxifen injection, from 7 males and 4 females for each group
Publication Title
No associated publication
Sample Metadata Fields
Specimen part
View Samples DRP003489- Mus musculus
- 2 Downloadable Samples
- Illumina Genome Analyzer IIx
Description
Transcriptome analysis of Hematopoietic stem cells [HSC (LSK)] (Ctrl (flox/flox, MxCre-) vs cKI (Q367P)(flox/flox, MxCre+), 3 months post pIpC injection
Publication Title
No associated publication
Sample Metadata Fields
Specimen part
View Samples DRP003182- Mus musculus
- 2 Downloadable Samples
- Illumina Genome Analyzer IIx
Description
Transcriptome analysis of hematopoietic stem cells [HSC (LSK)] (Eed cKO (flox/flox ERT2Cre+) vs control (flox/flox ERT2Cre-). Mice were injected with tamoxifen for five consecutive days and then sacrificed two days after the final injection.
Publication Title
No associated publication
Sample Metadata Fields
Specimen part
View Samples DRP003243- Mus musculus
- 2 Downloadable Samples
- Illumina Genome Analyzer IIx
Description
Transcriptome analysis of hematopoietic stem cells [HSC (LSK; Lin-, c-Kit+, Sca-1+ bone marrow cells)] (Eed I363M/+ vs Eed +/+) (males, 11-14 weeks of age)
Publication Title
No associated publication
Sample Metadata Fields
Sex, Cell line
View Samples