Collaborative effects of SETBP1-D868N with ASXL1-MT in inducing AML

Using a mouse BMT model, we examined the in vivo effect of simultaneous expression of ASXL1-MT and SETBP1-D868N. All of the mice transplanted with BM cells expressing both ASXL1-MT and SETBP1-D868N died of acute leukemia after a short latency, while all of the mice transplanted with BM cells expressing either ASXL1-MT or SETBP1-D868N alone survived for 6 months after transplantation. To elucidate the mechanism for leukemogenesis induced by the combination of ASXL1-MT and SETBP1-D868N, we compared the expression profile of BM cells of AML mice induced by both ASXL1-MT and SETBP1-D868N with that of BM cells of MDS mice induced by ASXL1-MT.

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