Study was carried out to examine how E2 and TNFa together influence gene expression in breast cancer cells compared to either factor alone.
Positive cross-talk between estrogen receptor and NF-kappaB in breast cancer.
No sample metadata fields
View SamplesThis SuperSeries is composed of the SubSeries listed below.
Toward Signaling-Driven Biomarkers Immune to Normal Tissue Contamination.
Disease, Disease stage
View SamplesGene expression data from the Nurses' Health Study
PAM50 Molecular Intrinsic Subtypes in the Nurses' Health Study Cohorts.
Disease stage, Treatment
View SamplesYAP knockdown in HUVEC elicits proliferation and cell cycle preogression defects. YAP deficient cells caused arrest in G1 and defects in S-phase entry. The microarray analysis was conducted to identify potential YAP targets that are involved in HUVEC cell cycle regulation
YAP regulates S-phase entry in endothelial cells.
Specimen part, Treatment
View SamplesThis experiment is to examine the effect of PARP inhibitor and Myc shRNA knockdown on transcriptome profiles in MYC-amplified human GBM stem cells MGG4. Overall design: There are totally 4 samples. GBM cell MGG4 expressing scramble shRNA or shRNA targeting Myc were grown in doxycycline (Dox, 1 mg/ml) for 6 days, treated with olaparib (Ola, 10 microM) or DMSO for 24h, and harvested for RNA extraction, followed by RNA sequencing
Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma.
Cell line, Treatment, Subject
View SamplesWe report the transcriptome of single pancreatic cells at embryonic day e13.5 Overall design: Single cells mRNA of wild-type mouse pancreata at embryonic day 13.5
Single cell transcriptomic profiling of mouse pancreatic progenitors.
Specimen part, Cell line, Subject
View SamplesPurpose: To determine effects of arsenic on gene expression in polarized primary human bronchial epithelial (HBE) cells and impact on transcriptional response to Pseudomonas aeruginosa infection Methods: mRNA profiles of HBE cells from 6 donors exposed to 0, 5, 10 or 50 ug/L total arsenic +/- Pseudomonas aeruginosa (48 samples) were generated using Illumina sequencing, aligned in CLC Genomics workbench and analyzed for DE in EdgeR Findings: 20-30 million reads were mapped per sample and transcripts were identifed that were significantly differentially expressed in response to arsenic and Pseudomonas aeruginosa Overall design: Gene expression profiles of HBE cells from 6 donors exposed to three concentrations of arsenic +/- Pseudomonas were generated using mRNA sequencing
Arsenic alters transcriptional responses to Pseudomonas aeruginosa infection and decreases antimicrobial defense of human airway epithelial cells.
Sex, Specimen part, Subject
View SamplesThis SuperSeries is composed of the SubSeries listed below.
Coassembly of REST and its cofactors at sites of gene repression in embryonic stem cells.
Cell line, Treatment
View SamplesAnalysis of gene expression profiling upon REST shRNA knockdown in mouse ES cells for 72 hours,
Coassembly of REST and its cofactors at sites of gene repression in embryonic stem cells.
Cell line, Treatment
View SamplesThis SuperSeries is composed of the SubSeries listed below.
The long noncoding RNA RMST interacts with SOX2 to regulate neurogenesis.
Cell line, Treatment
View Samples