Description

We report that after cancer cells are exposed to a transient pulse (5h) of the pro-inflammatory cytokine IFN?, they continue up-regulating genes in the antigen presentation pathway for days after abrogation of the original signal. We discovered that a new mechanism of cell-to-cell communication, cytokine catch-and-release, explains this surprising result. Overall design: Examination of IFN?-induced gene expression over multiple timepoints in mouse melanoma cells

Publication Title

Catch and Release of Cytokines Mediated by Tumor Phosphatidylserine Converts Transient Exposure into Long-Lived Inflammation.

Sample Metadata Fields

Specimen part, Cell line, Subject