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SRP171933
Mus musculus
54 Downloadable Samples
NextSeq 500
Description
Transcriptionally similar subpopulations of exhausted CD8+ T-cells are found in chronic viral infection and tumors Overall design: RNA-seq analysis of progenitor exhausted and terminally exhausted CD8+ T-cells isolated from spleens of mice chronically infected with LCMV Clone 13 (day 30 post-infection) or isolated from B16-ova tumors (day 22 post tumor implantation), with or without anti-PD-1 treatment
Publication Title
Subsets of exhausted CD8<sup>+</sup> T cells differentially mediate tumor control and respond to checkpoint blockade.
Sample Metadata Fields
Specimen part, Cell line, Subject
View Samples- Mus musculus
- 4 Downloadable Samples
- NextSeq 500
Description
Distinct populations of progenitor exhausted (Tcf1+Tim-3-) and terminally exhausted (Tcf1-Tim-3+) CD8+ T-cells occur in B16-OVA tumors Overall design: Profiling of CD8+ T-cells from day 10 and day 20 B16-OVA mouse melanoma tumors
Publication Title
Subsets of exhausted CD8<sup>+</sup> T cells differentially mediate tumor control and respond to checkpoint blockade.
Sample Metadata Fields
Specimen part, Cell line, Subject
View Samples- Homo sapiens
- 12 Downloadable Samples
- NextSeq 500
Description
The purpose of this study is to understand the effects of adrenergic signaling on the transcriptome of cell line models postulated to be the cells of origin of epithelial ovarian cancers using RNA-Seq. Here we explored the effects of the stress-related hormone, norepinephrine, on normal human ovarian and fallopian tube surface epithelial cellss. We investigated the early transcriptional response to norepinephrine in normal immortalized ovarian surface epithelial cells and fallopian tube secretory cells. RNA-Seq data of treated and untreated cells were analyzed to identify genes with differential expression. Overall design: RNA-seq data from ovarian surface epithelial cells and fallopian tube epithelial cells after treatment with 1µM norepinephrine for 1 hour (or mock-treatment). Three independent replicates were performed for each condition and cell line.
Publication Title
Early transcriptional response of human ovarian and fallopian tube surface epithelial cells to norepinephrine.
Sample Metadata Fields
Specimen part, Cell line, Treatment, Subject
View Samples