To develop an in vitro model for developmental toxicity testing, we characterized gene expression changes during mouse embryonic stem cell (mESC) differentiation and their modulation by developmental toxicants.
Transcriptomic characterization of C57BL/6 mouse embryonic stem cell differentiation and its modulation by developmental toxicants.
Specimen part
View SamplesTo unravel the mechanisms of thalidomide developmental toxicity, we used microarrays to study transcriptomic changes induced by thalidomide during mouse embryonic stem cell (mESC) differentiation.
Thalidomide induced early gene expression perturbations indicative of human embryopathy in mouse embryonic stem cells.
Specimen part
View SamplesTranscriptomic changes induced by silver nanoparticles (AgNPs) during spontaneous differentiation of mouse embryonic stem cells (ESCs) were characterized and compared to those induced by Ag+ under otherwise identical conditions.
No associated publication
Specimen part, Treatment
View Samples