submitter_institution:UNSW Sydney Results

Showing of 45 results

Sort by

Hide non-downloadable experiments

Filters

Technology

Microarray (656)

Platform

Affymetrix Bovine Genome Array (bovine) (124)

Affymetrix Mouse Genome 430 2.0 Array (mouse4302) (104)

Affymetrix Mouse Gene 2.1 ST Array (mogene21st) (79)

(lluminahumanht12v3.0expressionbeadchip[ilmngenesymbol) (60)

Illumina HumanHT-12 V4.0 expression beadchip (reannotation) (60)

Affymetrix Human Gene 1.0 ST Array (hugene10st) (56)

Includes Publication

GSE108983

Reprogramming of heterologous cells by defined factors to generate lineage-restricted biomolecules

Mus musculus
8 Downloadable Samples
Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Description

The ability of transcriptional regulators to drive lineage conversion of somatic cells offers great potential for the treatment of human disease. While current research in this field is focused on the generation of induced pluripotent stem cells or direct lineage transdifferentiation, less attention has been paid to the possibility of reprogramming cells to produce cytokines, growth factors and hormones. To explore the concept of switching on specific target genes in heterologous cells, we developed a model system to screen candidate factors for their ability to activate the archetypal megakaryocyte-specific chemokine platelet factor 4 (PF4) in fibroblasts. We found that co-expression of the transcriptional regulators GATA1 and FLI1 resulted in a significant increase in levels of PF4, which became magnified over time. We also determined that inclusion of a third factor, TAL1, further enhanced upregulation of PF4 expression. Our study therefore identified of TAL1 as an important component in the combination of transcriptional regulators that contribute to megakaryocyte programming, and demonstrated that such combinations can be used to produce potentially beneficial chemokines in readily available heterologous cell types.

Publication Title

Partial reprogramming of heterologous cells by defined factors to generate megakaryocyte lineage-restricted biomolecules.

Sample Metadata Fields

Time

View Samples

GSE25616

Liver expression data from lactating QSi5 mice

Mus musculus
10 Downloadable Samples
Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Description

The liver plays a crucial role in energy partitioning and is particularly important for the increased demand from the mammary gland during lactation. The present study identifies genes associated with negative energy balance in lactating mice.

Publication Title

No associated publication

Sample Metadata Fields

No sample metadata fields

View Samples

GSE50083

Microarray analysis of monoclonal K562 lines transfected with pEF1a or pEF1a-Pu.2

Homo sapiens
6 Downloadable Samples
Affymetrix Human Gene 1.0 ST Array (hugene10st)

Description

Ectopic expression of the novel Pu.1 isoform Pu.2 in K562 was performed to investigate the biological function and importance of this novel protein

Publication Title

No associated publication

Sample Metadata Fields

Cell line

View Samples

GSE114384

Expression data of sheep exposed to Mycobacterium avium subsp. Paratuberculosis

Ovis aries
124 Downloadable Samples
Affymetrix Bovine Genome Array (bovine)

Description

In this study, consistent gene expression changes were analysed to identify gene-to-gene interaction and functional pathway relationships associated with the MAP exposure outcomes of either a paucibacillary or a multibacillary disease form or sheep resilient to disease. The results suggest that although groups of genes are differentially changed in the MAP exposed sheep regardless of clinical outcome, there are distinct variations in gene expression patterns between the paucibacillary and multibacillary forms of disease and of particular note was the finding that MAP exposed animals with evidence of recovery or resilience respond to MAP exposure with a pattern of gene and molecular pathway interactions distinct from those animals that progress to clinical paratuberculosis.

Publication Title

No associated publication

Sample Metadata Fields

Specimen part, Disease, Treatment

View Samples

GSE31130

Non-overlapping progesterone receptor cistromes contribute to cell-specific transcriptional outcomes in breast cells

Homo sapiens
60 Downloadable Samples
Illumina HumanHT-12 V4.0 expression beadchip, Illumina HumanHT-12 V3.0 expression beadchip

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Non-overlapping progesterone receptor cistromes contribute to cell-specific transcriptional outcomes.

Sample Metadata Fields

Specimen part, Cell line

View Samples

GSE85998

Expression data from mouse liver

Mus musculus
47 Downloadable Samples
Affymetrix Mouse Gene 2.1 ST Array (mogene21st)

Description

Livers from 15 month old mice mainatined on one of 25 different diets varying in protein, carbohydrate, fat (P,C,F) and energy content were analysed. Energy content was categorised as low (8kJ/g), medium (13kJ/g) or high (17kJ/g) Mice were placed on diet from 3 weeks of age and a subset culled for various analyses. The rest of the cohort was allowed to live out their natural life to assess lifespan.

Publication Title

Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework.

Sample Metadata Fields

Specimen part

View Samples

GSE31128

Progestin regulation of gene expression in breast cancer and minimally transformed breast cell lines

Homo sapiens
48 Downloadable Samples
Illumina HumanHT-12 V3.0 expression beadchip

Description

Time course of response to synthetic progestin ORG2058 in T-47D and ZR-75-1 breast cancer cell lines and in two PR positive clones of the MCF-10A cell line: AB9 and AB32.