CD19 positive B cells were sorted from spleens in wild type mice and conditional konckout PRMT7 mice. RNA-seq experiments were performed to identify the differential expressing genes.
Histone Arginine Methylation by PRMT7 Controls Germinal Center Formation via Regulating Bcl6 Transcription.
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View Samplestranscriptional profile of both macrophages (M) and endothelial end cells (EC) between three different lesion stages (uninjured control (con), upon macrophage arrival (arr), and during macrophage traction (tra)).
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View SamplesThe objective of our study was to identify a lncRNA expression profile in tissue of patients with nasopharyngeal carcinoma.
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Sex, Specimen part
View SamplesAs an ancient winning strategy of microorganisms, glucose repression mechanism has become specialized to perfection in Saccharomyces cerevisiae. The galactose (GAL) metabolism network is stringently regulated by glucose repression in yeast and has been a classic system for studying gene regulation. We show here that the population of S. cerevisiae living in fermented milks has autonomously reinstated an ancient version of the structural GAL genes through introgression. The introgressed GAL network has completely abolished the glucose repression and conversed from a strictly inducible to a constitutive system through coordinative polygenic changes in the regulatory components of the network, including transitions in the upstream repressing sequence site of GAL4 that impair Mig1p-mediated repression and loss of function of the inducer Gal3p and the repressor Gal80p. In addition, the introgressed GAL2 gene has been duplicated while the native HXT6 and HXT7 genes have been inactivated, resulting in galactose-over-glucose preference and elevated galactose utilization rate. Relying on the reverse evolution of the GAL network, the non-lactose fermenting yeast has become a dominant species co-existing with other lactose fermenting microorganisms in fermented milks. Our results also provide new clues for developing yeast strains devoid of barriers to co-utilization of different sugars.
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Specimen part, Disease, Cell line
View SamplesThe differential expression of gene in bone marrow derived macrophages from Ckip-1 KO mice and WT mice.
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Sex, Age, Specimen part, Cell line
View SamplesTo obtain a comprehensive knowledge about the function of ZmASDP in maize seed development, the gene expression profile of 15-DAP NC and ZmASDP KD kernels was compared by RNA-seq analysis.
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Age, Specimen part
View SamplesTranscriptomic analysis of ZmUbi:ZmNAC111 transgenic maize under under well-watered and 2h dehydration stress conditions
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Specimen part
View SamplesSingle cell RNA-seq was applied for studying the transcriptomic profile in early zebrafish PGCs(primordial germ cells) by choosing three time points during zebrafish embryonic development. The three time points were 6hpf(hours post fertilization, also called shield stage), 11hpf(also called 3-somite stage) and 24hpf(also called prim-5 stage).
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Sex, Specimen part, Cell line
View SamplesPex3 plays an essential role in peroxisomal membrane proteins (PMPs) import. Loss of Pex3 leads to a spermatogenic arrest.
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Sex, Specimen part, Cell line
View SamplesThis study presented the differentially expressed genes post maize infected by Rhizoctonia solani.
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Specimen part
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