Human NK cells were sorted into CD56dim and CD56bright NK cell subpopulations. In order to define characteristics of both populations gene profiling was performed using Affymetrix arrays U133a and U133B.
Gene and protein characteristics reflect functional diversity of CD56dim and CD56bright NK cells.
Specimen part
View SamplesWe purified five subsets representing the main stages of human precursor-B-cell differentiation and CD34+lin- cord blood cells. The immunoglobulin (Ig) gene rearrangement status was determined using TaqMan quantitative PCR and GeneScan analysis. To gain more insight in the networks of genes that initiate and/or regulate the different types of Ig gene rearrangements, we analyzed their gene expression profiles by correlating the initiation of Ig gene rearrangements with specific upregulation of transcription factors. In addition to previously described transcription factors, we identified 16 candidate genes involved in initiation and/or regulation of Ig gene rearrangements.
No associated publication
Specimen part
View SamplesTo gain more insight into initiation and regulation of T cell receptor (TCR) gene rearrangement during human T cell development, we analyzed TCR gene rearrangements by quantitative PCR analysis in nine consecutive T-cell developmental stages, including CD34+ lin- cord blood cells as a reference. The same stages were used for gene expression profiling using DNA microarrays.
New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling.
Specimen part
View SamplesInvestigation of pH induced gene expression changes in bone-marrow-derived macrophages
No associated publication
Sex, Age, Specimen part, Disease, Treatment
View SamplesInverstigation of differential gene expresseion in tumor-associated macrophages of WT-and Icer- knockout mice
No associated publication
Sex, Age, Specimen part, Disease
View SamplesNormal human colorectal mucosa was sampled at points along the colon.
Map of differential transcript expression in the normal human large intestine.
Specimen part
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No associated publication
No sample metadata fields
View SamplesT cell lymphoma
PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis.
Sex, Specimen part, Cell line
View SamplesTo understand the molecular mechanisms underlying AS progression, we assessedblood collected from disease and normal groups and obtained pulmonary arteries fromAS and normal broilers for pathological observation and RNA-seq analysis.
No associated publication
Sex, Specimen part, Cell line
View SamplesDifferencies between groups between pre and post haematopoietic stem cell transplantation children
Genetic Background of Immune Complications after Allogeneic Hematopoietic Stem Cell Transplantation in Children.
Specimen part, Disease stage
View Samples