This study aims to compare the global expression signature of protein coding genes between oral cancers from carcinogen-induced mice and human patients. Combinatorial treatment of 4NQO and arecoline for 8 weeks consistently induced the formation of mouse oral cancer with morphology and pathology resembling human oral squamous cell carcinoma. In this dataset, 5 mouse normal tongue and 7 tumor samples were used and Illumina Mouse Ref-8 cDNA microarray was conducted.
No associated publication
Age, Specimen part
View SamplesDisabled-2 (DAB2) is up-regulated when ESC were cocultured with OP9 stromal cells for mesodermal colony formation. Expression of DAB2 short hairpin small interfering RNA (shDAB2) altered ESC cell-cell adhesion that subsequently affected colony formation and mesoderm differentiation competence.
No associated publication
Specimen part
View SamplesThis SuperSeries is composed of the SubSeries listed below.
A novel molecular signature identified by systems genetics approach predicts prognosis in oral squamous cell carcinoma.
Disease, Disease stage
View SamplesIn order to aid the development of patient-tailored diagnostics and therapeutics, we attempted to identify a genetic signature associated with disease prognosis in OSCC. A genome-wide analysis of transcription with the Affymetrix GeneChip Human Gene 1.0 ST Array was conducted.
A novel molecular signature identified by systems genetics approach predicts prognosis in oral squamous cell carcinoma.
Disease, Disease stage
View SamplesComparison of the gene expression profiles with meningiomas of different grading.
No associated publication
Specimen part, Disease stage
View SamplesThis SuperSeries is composed of the SubSeries listed below.
No associated publication
Specimen part
View SamplesThe underlying change of gene network expression of Guillain-Barre syndrome (GBS) remains elusive. We sought to identify GBS-associated gene networks and signalling pathways by analyzing the transcriptional profile of leukocytes in the patients with GBS.
Identification of gene networks and pathways associated with Guillain-Barré syndrome.
Sex, Age, Specimen part, Race
View SamplesThis study aimed to evaluate the change of liver status in the presence of hepatitis B viral proteins
No associated publication
Specimen part
View SamplesThis SuperSeries is composed of the SubSeries listed below.
No associated publication
No sample metadata fields
View SamplesSingle nucleotide polymorphisms in intron 1 of the fat mass and obesity-associated (FTO) gene were found to be associated with an increased risk of adult obesity. Enhanced FTO expression in mice leads to hyperphagia, increased fat mass, and higher body weight. Neuronal-specific FTOdeleted mice have an identical lean body weight phenotype to global FTO-deleted mice. The physiological role of adipose FTO in the homeostasis of energy regulation remains to be elucidated.
Loss of FTO in adipose tissue decreases Angptl4 translation and alters triglyceride metabolism.
Sex, Age, Specimen part
View Samples