Plant seeds prepare for germination already during seed maturation. We performed a detailed transcriptome analysis of barley grain maturation, desiccation and germination in two tissue fractions (endosperm/aleurone = e/a and embryo = em) using the Affymetrix barley1 chip.
Barley grain maturation and germination: metabolic pathway and regulatory network commonalities and differences highlighted by new MapMan/PageMan profiling tools.
No sample metadata fields
View SamplesResponse of JHCO9 and JHOC5 cells to infection with NT (control) lentivirus or one of two knockdown lentiviruses, SPINK1 KD or IL-6 KD.
Targeting an autocrine IL-6-SPINK1 signaling axis to suppress metastatic spread in ovarian clear cell carcinoma.
Specimen part, Cell line
View SamplesUterine receptivity implies a dialogue between the hormonally primed maternal endometrium and the free-floating blastocyst. Endometrial stromal cells proliferate, avert apoptosis, and undergo decidualization in preparation for implantation; however, the molecular mechanisms that underlie differentiation into the decidual phenotype remain largely undefined. The Notch family of transmembrane receptors transduce extracellular signals responsible for cell survival, cell-to-cell communication, and trans-differentiation, all fundamental processes for decidualization and pregnancy. Using a murine artificial decidualization model, pharmacological inhibition of Notch signaling by gamma-secretase inhibition resulted in significantly decreased deciduoma. Furthermore, a progesterone receptor (PR)-Cre Notch1 bigenic (Notch1d/d) confirmed a Notch1-dependant hypomorphic decidual phenotype.
Notch1 mediates uterine stromal differentiation and is critical for complete decidualization in the mouse.
Sex, Age, Specimen part
View SamplesResponse of pancreas cancer cells to treatment with recombinant MMP3
Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma.
Specimen part, Cell line, Treatment
View SamplesExpression profiles of anti-TNF responders were compared to profiles of anti-TNF non-responders in order to identify an expression signature for anti-TNF response
Validation study of existing gene expression signatures for anti-TNF treatment in patients with rheumatoid arthritis.
Specimen part, Disease, Disease stage, Treatment
View SamplesWe performed total RNA-Seq of murine Th1 cells which were four times reactivated in vitro in the presence of irradiated APC'srepeatedly activated in vitro. Overall design: CD4+CD62Lhi (naive) cells were isolated from C57BL/6 mice, activated with aCD3 and aCD28 an cultured under Th1 polarizing conditions in the presence of irradiated APCs. Every sixth day cells were harvested, restimulated with aCD3 and aCD28 and cultured under Th1 polarizing conditions in the presence of irradiated APCs APCs. After four rounds of restimulation, total RNA was extracted and cDNA libraries for total RNA sequencing were generated using “TruSeq® Stranded Total RNA Library” kit (Illumina, San Diego, CA, USA).
MicroRNA-31 Reduces the Motility of Proinflammatory T Helper 1 Lymphocytes.
Specimen part, Subject
View SamplesResponse of mouse mammary epithelial cells to treatment with MMP3
ROS-induced epithelial-mesenchymal transition in mammary epithelial cells is mediated by NF-kB-dependent activation of Snail.
Specimen part, Treatment
View SamplesThis SuperSeries is composed of the SubSeries listed below.
Regulation of epithelial-mesenchymal transition in breast cancer cells by cell contact and adhesion.
Specimen part, Cell line
View SamplesResponse of mouse mammary epithelial cells to different cell densities and treatment with MMP3
Regulation of epithelial-mesenchymal transition in breast cancer cells by cell contact and adhesion.
Specimen part, Cell line
View SamplesResponse of mammary epithelial cells to different cell densities
Regulation of epithelial-mesenchymal transition in breast cancer cells by cell contact and adhesion.
Specimen part, Cell line
View Samples