Description

Continuous stress caused by smoking induces changes in the cell population of small airway epithelium, with basal cell hyperplasia and goblet cell metaplasia at the expense of ciliated cells, and there is now compiling evidence that basal cells play a key role in the early pathogenesis of Chronic Obtructive Pulmonary Disease (COPD).

Publication Title

Microarray analysis identifies defects in regenerative and immune response pathways in COPD airway basal cells.

Sample Metadata Fields

Specimen part, Disease stage