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GSE74259
Saccharomyces cerevisiae
13 Downloadable Samples
Affymetrix Yeast Genome 2.0 Array (yeast2)
Description
Microarray analysis was used for a global investigation of the cellular effects of acute 3-trifluoromethyl-4-nitrophenol (TFM) exposure on Saccharomyces cerevisiae over time. TFM is used to control sea lamprey (Petromyzon marinus) populations in the Lake Champlain and Great Lakes regions. Little is known about the changes in gene expression due to TFM exposure so this time course microarray study was performed to reveal significantly altered patterns of gene expression when yeast cultures were exposed to 0.05mM TFM over four hours.
Publication Title
Exposure to the lampricide 3-trifluoromethyl-4-nitrophenol results in increased expression of carbohydrate transporters in Saccharomyces cerevisiae.
Sample Metadata Fields
Time
View Samples- Homo sapiens
- 648 Downloadable Samples
IlluminaHiSeq2000
Description
Single cell RNA-sequencing of human tonsil Innate lymphoid cells (ILCs) from three independent tonsil donors. Overall design: Sequencing libraries were prepared from FACS sorted individual ILCs with the Smart-Seq2 protocol (Picelli et al. Nature Methods 2013)
Publication Title
The heterogeneity of human CD127(+) innate lymphoid cells revealed by single-cell RNA sequencing.
Sample Metadata Fields
No sample metadata fields
View Samples- Homo sapiens
- 53 Downloadable Samples
- Illumina HiSeq 2000
Description
We report the transcriptome analysis of epidermal CD8 tissue resident memory T (TRM) cells from healthy human skin. Specifically, epidermal CD8+CD103+CD49a+ and CD8+CD103+CD49- TRM cells from healthy human skin were sorted by FACS. Differential gene expression analysis revealed functional dichotomy of epidermal CD8+CD103+CD49a+ and CD8+CD103+CD49- TRM cells. Overall design: Analysis of differentially expressed genes between epidermal CD8+CD103+CD49a+ and CD8+CD103+CD49- T cells from healthy human skin, biological replicates (n=7) (healthy skin donors).
Publication Title
CD49a Expression Defines Tissue-Resident CD8<sup>+</sup> T Cells Poised for Cytotoxic Function in Human Skin.
Sample Metadata Fields
Specimen part, Subject
View Samples- Homo sapiens
- 6 Downloadable Samples
- Illumina HiSeq 4000
Description
We performed transcriptome analysis of Human Aortic Endothelial Cells after siRNA mediated knockdown of MTHFD2. We identified MTHFD2 as a key driver for a gene cluster which integrates mitochondrial one-carbon metabolism, serine synthesizing enzymes as well as common amino acid and ER stress response genes. Overall design: Human Aortic Endothelial Cells were treated with three different siRNAs against MTHFD2 or scramble for 72 h
Publication Title
Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells.
Sample Metadata Fields
Treatment, Subject
View Samples