Pilocytic astrocytomas (PAs) are the most common glioma in children. While many PAs are slow growing or clinically indolent, others exhibit more aggressive features with tumor recurrence and death. In order to identify genetic signatures that might predict PA clinical behavior, we performed gene expression profiling on 41 primary PAs arising sporadically and in patients with neurofibromatosis type 1 (NF1). While no expression signature was found that could discriminate clinically-aggressive or recurrent tumors from more indolent cases, PAs arising in patients with NF1 did exhibit a unique gene expression pattern. In addition, we identified a gene expression signature that stratified PAs by location (supratentorial versus infratentorial).
Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin.
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View SamplesAffymetrix Mouse Genome 430 2.0 GeneChip microarrays were used to analyze murine neocortical and cerbellar astrocytes generated from postnatal (PN) day 1 wild-type (ICR) pups.
Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin.
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View SamplesWe examine the transcriptional profile of lung Tgd17 cells from mice that are deficient for Aire compared to wild-type mice. Overall design: Duplicate samples of 500 sorted lung resident CD27- Vg1,2,4,5- gd T cells from
Aire Inhibits the Generation of a Perinatal Population of Interleukin-17A-Producing γδ T Cells to Promote Immunologic Tolerance.
Sex, Age, Specimen part, Cell line, Subject
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