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accession-icon SRP112700
Gene expression profiling of S2 cells and S2 cells expressing AbdA
  • organism-icon Drosophila melanogaster
  • sample-icon 6 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2000

Description

We sought to determine the genes regulated by the Drosophila Hox protein AbdA in a homogenous cell system. S2-DRSC cells that have no Hox expression were stably transfected with HA-tagged AbdA under the control of a metallothionein promoter. Overall design: S2-DRSC cells are stably transfected with HA-tagged AbdA (S2-DRSC:AbdA). S2 and S2-AbdA cells are analysed for gene expression in the absence (S2-DRSC) and presence (S2-DRSC-HA::AbdA) of AbdA

Publication Title

Human ZKSCAN3 and Drosophila M1BP are functionally homologous transcription factors in autophagy regulation.

Sample Metadata Fields

Cell line, Treatment, Subject

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accession-icon GSE32201
Transcriptome of early postnatal brain development of eIF2B-R132H/R132H mutant mice relative to wild-types.
  • organism-icon Mus musculus
  • sample-icon 18 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Description

Genome-wide mRNA expression in brains of wild-type and eIF2B-R132H/R132H mutant mice (Geva et al., BRAIN 133 (8), 2010) profiled at postnatal (P) days 1, 18 and 21 to reflect the early proliferative stage prior to white matter establishment (P1) and the peak of oligodendrocye differentiation and myelin synthesis (P18 and P21).

Publication Title

A point mutation in translation initiation factor eIF2B leads to function--and time-specific changes in brain gene expression.

Sample Metadata Fields

Specimen part

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accession-icon GSE30314
Expression data from mouse heart with and without GATA4 S105A mutation; with and without adrenergic stress
  • organism-icon Mus musculus
  • sample-icon 8 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Description

Serine 105 phosphorylation of GATA4 is necessary for stress-induced cardiac hypertrophy in vivo.

Publication Title

Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo.

Sample Metadata Fields

Age, Specimen part

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accession-icon GSE23028
Analysis of Ppif-/- hearts
  • organism-icon Mus musculus
  • sample-icon 6 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Description

To identify differences in gene expression between peptidylprolyl isomerase F (cyclophilin D; Ppif)-null hearts and WT control hearts.

Publication Title

Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice.

Sample Metadata Fields

Age, Specimen part

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accession-icon GSE71174
Affymetrix GeneChip Mouse Gene 1.0 arrays of RNA extracted from gastrocnemius muscle of 4 global Ppp3cb KO mice and 4 corresponding WT littermates, and 4 skeletal muscle-specific Ppp3r1Mlc1fCre KO and 4 corresponding WT littermates.
  • organism-icon Mus musculus
  • sample-icon 16 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Description

Global deficiency of catalytic subunit Ppp3cb, and tissue-specific ablation of regulatory subunit Ppp3r1 from skeletal muscle but not adipose tissue or liver led to protection from high-fat diet induced obesity and comorbid sequel.

Publication Title

Calcineurin Links Mitochondrial Elongation with Energy Metabolism.

Sample Metadata Fields

Sex, Specimen part

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