We analyzed a role of histone deacetylases in alternative splicing regulation. Using human exon arrays we identified a list of 683 genes whose splicing changes after HDAC inhibition with sodium butyrate.
Histone deacetylase activity modulates alternative splicing.
Cell line
View SamplesWe analyzed a role of Brd2 protein in transcription and alternative splicing. 289 genes change alternative splicing after Brd2 knockdown and 1459 genes alter gene expression compared to cells treated with negative control siRNA.
The C-terminal domain of Brd2 is important for chromatin interaction and regulation of transcription and alternative splicing.
Cell line
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