The abstract of the associated publication (Selga E, No V, Ciudad CJ. Biochemical Pharmacology, 2008) is the following:
Transcriptional regulation of aldo-keto reductase 1C1 in HT29 human colon cancer cells resistant to methotrexate: role in the cell cycle and apoptosis.
No sample metadata fields
View SamplesA summary of the work associated to these microarrays is the following:
Coffee polyphenols change the expression of STAT5B and ATF-2 modifying cyclin D1 levels in cancer cells.
Cell line, Treatment
View SamplesThe identification of new agents that may modulate the progression of cancer cell growth is of great interest. In this regard, dietary agents can be utilized to identify molecular targets to be used as part of a chemopreventive strategy. Walnuts contain several bioactive compounds, including pedunculagin, a polyphenol metabolized by microbiota to form urolithins, namely urolithin A (UA). We performed a genomic analysis to study the effect of UA on androgen-dependent LNCaP prostate adenocarcinoma cells. Cells were incubated with 40M UA for 24 hours, then, RNA was extracted. RNA samples were processed in the automated Biomek FX System (Beckman Coulter), where aRNA was produced, and labeled with Biotin, purified , fragmented and hybridized onto HG U219-24 Array, using the GeneChip HT 3IVT Express Kit . Afterwards, the GeneTitan Multi-Channel (MC) Instrument (Affymetrix) was used to hybridize, wash , stain , and scan the arrays. Microarray results were analyzed using the GeneSpring GX v13.0 software.
Urolithin A causes p21 up-regulation in prostate cancer cells.
Specimen part, Cell line
View SamplesA summary of the work associated to these microarrays is the following:
Role of caveolin 1, E-cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells.
Specimen part, Cell line
View SamplesThis SuperSeries is composed of the SubSeries listed below.
Networking of differentially expressed genes in human cancer cells resistant to methotrexate.
Specimen part, Cell line
View SamplesA summary of the work associated to these microarrays is the following:
Networking of differentially expressed genes in human cancer cells resistant to methotrexate.
Specimen part, Cell line
View SamplesA summary of the work associated to these microarrays is the following:
Networking of differentially expressed genes in human cancer cells resistant to methotrexate.
Specimen part, Cell line
View SamplesA summary of the work associated to these microarrays is the following:
Networking of differentially expressed genes in human cancer cells resistant to methotrexate.
Specimen part, Cell line
View SamplesA summary of the work associated to these microarrays is the following:
Networking of differentially expressed genes in human cancer cells resistant to methotrexate.
Specimen part, Cell line
View SamplesA summary of the work associated to these microarrays is the following:
Networking of differentially expressed genes in human cancer cells resistant to methotrexate.
Specimen part, Cell line
View Samples