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accession-icon SRP101876
Transcriptomic analysis of depleted uranium effects on adult zebrafish and progeny
  • organism-icon Danio rerio
  • sample-icon 35 Downloadable Samples
  • Technology Badge IconIlluminaHiSeq1500

Description

This dataset describe the transcriptomic profiling of adult brain, gonades (testis and ovaries) of adult zebrafish exposed to 20µg/L of depleted uranium for 10 days. The progeny of the exposed fishes were also analysed at two-cells stage and 96 hours post fertilization Overall design: Biological samples (adult dissected tissues and whole embryos and larvae) were tested by RNASeq in duplicates

Publication Title

Whole transcriptome data of zebrafish exposed to chronic dose of depleted uranium.

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon SRP041150
Pseudomonas aeruginosa PA30 transcriptome in tap and waste water
  • organism-icon Pseudomonas aeruginosa
  • sample-icon 2 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 1000

Description

Aim of this project was to determine the transcriptional response of the isolate PA30 to tap water and waste water.

Publication Title

Whole genome and transcriptome analyses of environmental antibiotic sensitive and multi-resistant Pseudomonas aeruginosa isolates exposed to waste water and tap water.

Sample Metadata Fields

Specimen part

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accession-icon SRP041151
Pseudomonas aeruginosa PA49 transcriptome in tap and waste water
  • organism-icon Pseudomonas aeruginosa
  • sample-icon 2 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 1000

Description

Aim of this project was to determine the transcriptional response of the isolate PA49 to tap water and waste water.

Publication Title

Whole genome and transcriptome analyses of environmental antibiotic sensitive and multi-resistant Pseudomonas aeruginosa isolates exposed to waste water and tap water.

Sample Metadata Fields

Specimen part

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accession-icon GSE36547
Assessment of Ex Vivo Prostaglandin pathway activation in HSCs
  • organism-icon Homo sapiens
  • sample-icon 20 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

Transplantation with low numbers of hematopoietic stem cells (HSCs), found in many of the publically accessible cryopreserved umbilical cord blood (UCB) units, leads to delayed time to engraftment, high graft failure rates, and early mortality in many patients. A chemical screen in zebrafish identified the prostaglandin compound, 16,16 dimethyl prostaglandin E2 (dmPGE2), to be a critical regulator of hematopoietic stem cell homeostasis. We hypothesized that an ex vivo modulation with dmPGE2 prior to transplantation would lead to enhanced engraftment by increasing the effective dose of hematopoietic stem cells (HSCs) in cord blood. A phase I trial of reduced-intensity double UCB transplantation was performed to evaluate safety, rates of engraftment and fractional chimerism of dmPGE2 enhanced UCB units. To explore potential causes of the lack of enhanced efficacy in the first cohort, we characterized HSCs to determine whether the prostaglandin pathway was being activated under the ex vivo incubation conditions (4C, 10M dmPGE2, 60 minutes). Incubation conditions were identified (37C, 10M dmPGE2, 120 minutes) that maximize the activation of the prostaglandin pathway by dmPGE2 in human CD34+ cells.

Publication Title

Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation.

Sample Metadata Fields

Specimen part, Treatment

View Samples
accession-icon GSE46569
Prostaglandin-modulated umbilical cord blood hematopoietic stem cells
  • organism-icon Homo sapiens
  • sample-icon 9 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

Umbilical cord blood (UCB) is a valuable source of hematopoietic stem cells (HSCs) for use in allogeneic transplantation. Key advantages of UCB are rapid availability and less stringent requirements for HLA matching. However, UCB contains an inherently limited HSC count, which is associated with delayed time to engraftment, high graft failure rates and early mortality. 16,16 dimethyl prostaglandin E2 (dmPGE2) was previously identified to be a critical regulator of HSC homeostasis and we hypothesized that a brief ex vivo modulation could improve patient outcomes by increasing the effective dose of HSCs.

Publication Title

Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation.

Sample Metadata Fields

Specimen part

View Samples
accession-icon GSE48541
Prostaglandin dose response on hematopoietic stem cells (25 & 37 deg C)
  • organism-icon Homo sapiens
  • sample-icon 9 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

Umbilical cord blood (UCB) is a valuable source of hematopoietic stem cells (HSCs) for use in allogeneic transplantation. Key advantages of UCB are rapid availability and less stringent requirements for HLA matching. However, UCB contains an inherently limited HSC count, which is associated with delayed time to engraftment, high graft failure rates and early mortality. 16,16 dimethyl prostaglandin E2 (dmPGE2) was previously identified to be a critical regulator of HSC homeostasis and we hypothesized that a brief ex vivo modulation could improve patient outcomes by increasing the "effective dose" of HSCs.

Publication Title

Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation.

Sample Metadata Fields

Specimen part, Treatment

View Samples
accession-icon GSE46714
Prostaglandin duration required to elicit maximum response on hematopoietic stem cells
  • organism-icon Homo sapiens
  • sample-icon 6 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

Umbilical cord blood (UCB) is a valuable source of hematopoietic stem cells (HSCs) for use in allogeneic transplantation. Key advantages of UCB are rapid availability and less stringent requirements for HLA matching. However, UCB contains an inherently limited HSC count, which is associated with delayed time to engraftment, high graft failure rates and early mortality. 16,16 dimethyl prostaglandin E2 (dmPGE2) was previously identified to be a critical regulator of HSC homeostasis and we hypothesized that a brief ex vivo modulation could improve patient outcomes by increasing the effective dose of HSCs.

Publication Title

Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation.

Sample Metadata Fields

Specimen part, Treatment

View Samples
accession-icon GSE46634
Prostaglandin dose response on hematopoietic stem cells (4 deg C)
  • organism-icon Homo sapiens
  • sample-icon 4 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

Umbilical cord blood (UCB) is a valuable source of hematopoietic stem cells (HSCs) for use in allogeneic transplantation. Key advantages of UCB are rapid availability and less stringent requirements for HLA matching. However, UCB contains an inherently limited HSC count, which is associated with delayed time to engraftment, high graft failure rates and early mortality. 16,16 dimethyl prostaglandin E2 (dmPGE2) was previously identified to be a critical regulator of HSC homeostasis and we hypothesized that a brief ex vivo modulation could improve patient outcomes by increasing the effective dose of HSCs.

Publication Title

Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation.

Sample Metadata Fields

Specimen part

View Samples
accession-icon SRP093647
Non-Cell-Autonomous Tumor Suppressor Activity of the Homeobox Gene Cdx2 in the Gut
  • organism-icon Mus musculus
  • sample-icon 24 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 1000

Description

This dataset describe the transcriptomic profiling of cecum, stomach and ileum from wild type, cdx2 conditional knock out and cdx2 ; apc deficient mice, by mRNA-seq. Each condition was analyzed in triplicated experiment to analyze the role of cdx2 in colorectal cancer susceptibilities Overall design: Biological samples from dissected tissue were tested by RNASeq in triplicates resulting into a total of 24 samples.

Publication Title

The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms.

Sample Metadata Fields

Specimen part, Treatment, Subject

View Samples
accession-icon GSE56389
Development of the prethalamus is crucial for thalamocortical projection formationand is regulated by Olig2
  • organism-icon Mus musculus
  • sample-icon 6 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Description

Thalamocortical axons pass through the prethalamus in the first step of their neural circuit formation Although it has been supposed that the prethalamus is an intermediate target for thalamocortical projection formation, much less is known about the molecular mechanisms of this targeting.

Publication Title

Development of the prethalamus is crucial for thalamocortical projection formation and is regulated by Olig2.

Sample Metadata Fields

Specimen part

View Samples
...

refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

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Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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