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Accession IconSRP199744

Tissue resident macrophages promote renal cystic disease

Organism Icon Mus musculus
Sample Icon 2 Downloadable Samples
Technology Badge IconNextSeq 500

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Description
We show that resident macrophages accumulate in cilia mutant mice prior to cyst formation and that inhibition of resident macrophage accumulation reduces cystic kidney disease. Overall design: We analyzed gene expression of R2a (CD11c+) and R2b (CD11c-) resident macrophages isolated from adult, wild type mice. In these experiments, we isolated RNA from 6-8 mice and pooled the RNA together prior to sequencing.
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2
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