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Accession IconSRP197580

Group 3 innate lymphoid cells mediate early protective immunity against Mycobacterium tuberculosis

Organism Icon Homo sapiens
Sample Icon 24 Downloadable Samples
Technology Badge IconNextSeq 500

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Description
We report the phenotype of human lung ILC2 and ILC3 populations from individuals with tuberculosis (TB) and non-TB cancer controls. We find that ILC2s demonstrate moderate transcriptional differences in TB infection, whereas ILC3s demonstrate large differences. Overall design: ILC2s and ILC3s were purified by FACS from lung biopsies from TB infected lung tissue and peripheral healthy lung tissue from individuals with cancer. Low-input RNA-seq was performed on 1-3 replicates (dependent on cell number) on 5 individuals with TB infection and 2 controls.
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24
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