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Accession IconSRP193979

RNA-sequencing in human HepG2 hepatocytes reveals PPARa mediates transcriptome responsiveness of bilirubin

Organism Icon Homo sapiens
Sample Icon 12 Downloadable Samples
Technology Badge IconNextSeq 500

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Bilirubin is a potent antioxidant that reduces inflammation and the accumulation of fat. There have been reports of gene responses to bilirubin, which was mostly attributed to its antioxidant function. These RNA-sequencing studies investigated the impact biliverdin, which is rapidly reduced to bilirubin, has on transcriptome responses in human HepG2 hepatocytes in a PPARa-dependent fashion. This investigation reveals that transcriptome responses from the generation of bilirubin are mostly PPARa-dependent, and its antioxidant function regulates a smaller set of genes.
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