Long-term repopulation of Langerhans cell network following immune injury is inefficient and solely dependent upon influx of monocyte precursors

RNAseq gene expression following the repopulation of the langerhans cell network in immune deficient irradiated mice after ectopic injection of donor bone marrow cells Overall design: Allogeneic bone marrow transplantation with donor T cells leads to destruction of epidermal Langerhans cells (LC).  This study aimed to investigate if and how the LC network was replaced under these conditions. We demonstrated that monocytes entered the epidermis and differentiated into monocyte-derived LC that were homologous to the cells they had replaced.

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Ferrer IR, West HC, Henderson S, Ushakov DS, Santos E Sousa P, Strid J, Chakraverty R, Yates AJ, Bennett CL