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Accession IconSRP187955

Gene expression profile during senescence induced by LSG1 knockdown

Organism Icon Homo sapiens
Sample Icon 9 Downloadable Samples
Technology Badge IconIon Torrent Proton

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In the present study, we analyze the effect of knocking down LSG1 and KRas(V12D) overexpression in MRC5 cells in the transcriptome using Ampliseq RNA sequencig. We observed that shLSG1 induced a potent senescence response that is characterized by the activation of ER-Stress and cholesterol biosynthetic pathway Overall design: MRC5 were transfected with siRNA to knockdown the small GTPase LSG1. Total mRNA was extracted and expression profiles were analyzed.
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