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Accession IconSRP186268

GEF-H1-IRF5 mediated gene expression changes in BMDM by MDP recognition

Organism Icon Mus musculus
Sample Icon 12 Downloadable Samples
Technology Badge IconNextSeq 500

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Description
The transcription factor IRF5 is essential for immune defense against pathogens. Here, the authors show that the microtubule-associated factor GEF-H1 plays a critical role in host defense against Listeria monocytogenes in macrophages via activation of the IRF5 kinase IKKe Overall design: Examination of MDP stimulated BMDM from WT, Arhgef2 and Irf5 KO mice
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12
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