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Accession IconSRP183778

Coordinating Tissue Regeneration through TGF-ß Activated Kinase 1 (TAK1) In-activation and Re-activation

Organism Icon Mus musculus
Sample Icon 7 Downloadable Samples
Technology Badge IconIllumina HiSeq 2000

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Description
Our study reveals up-regulation of the TAK1 pathway when compared with the uninjured hindlimb in our model of trauma-induced heterotopic ossification (tHO) consisting of hindlimb Achilles' tendon transection with dorsal burn injury. Overall design: Using a model of musculoskeletal injury, we sought to determine the role that TGF-ß activated kinase 1 (TAK1) signaling has on MSC cellular differentiation and inappropriate tissue formation (heterotopic ossification).
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7
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