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Accession IconSRP173933

Regulation of cardiac transcription by thyroid hormone and Med13

Organism Icon Mus musculus
Sample Icon 32 Downloadable Samples
Technology Badge IconIllumina HiSeq 4000

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Description
Purpose: The objective of this study was to determine cardiac transcriptional pathways regulated in response to 1.) hypothyroidism and re-establishment of a euthyroid state and 2.) Med13-dependent cardiac transcriptional pathways regulated in response to hypothyroidism and re-establishment of a euthyroid state Overall design: Methods: WT and Med13 cardiac-specific knockout mice (Med13cKO) were put on a normal chow or PTU diet at 8 weeks of age for a duration of 4 weeks. A third group was put on a PTU diet for 4 weeks followed by 3 daily injections of T3.
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36
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