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Accession IconSRP170634

Transcriptome of a long-lived mutant nematode with severe mitochondrial deficiency

Organism Icon Caenorhabditis elegans
Sample Icon 15 Downloadable Samples
Technology Badge IconIllumina HiSeq 4000

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Description
Inhibition of insulin/IGF-1 signaling (IIS) represents a promising avenue for the treatment of mitochondrial diseases, although many of the molecular mechanisms underlying this beneficial effect remain elusive. Here, we analyze the transcriptome of a well established model for mitochondrial deficiency, gas-1(fc21) mutant nematodes, which when placed in a genetic context of IIS inhibition, undergo metabolic rewiring leading to a massive lifespan extension Overall design: 5 biological replicates each of wild-type, gas-1(fc21) and age-1(hx546);gas-1(fc21) mutant nematodes (L4 stage) were analyzed by RNA Next Generation Sequencing
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15
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