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Accession IconSRP170457

Mushroom body-specific RNA sequencing to examine the role of Bap60, a core SWI/SNF subunit, in the regulation of neuronal genes.

Organism Icon Drosophila melanogaster
Sample Icon 15 Downloadable Samples
Technology Badge IconNextSeq 500

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Description
RNA sequencing was used to identify genome wide transcriptional changes occurring in the Drosophila mushroom body in juvenile and mature adult flies expressing a mushroom body-specific RNAi knockdown of Bap60. The results of this analysis suggested a role for Bap60 in the regulation of neurodevelopmental genes during a critical time window of juvenile adult brain development. Overall design: RNA from mushroom body nuclei was sequenced from Drosophila melanogaster expressing a mushroom body-specific RNAi knockdown of Bap60 or mCherry (control) in both juvenile (2 and 3 replicates, respectively) and mature (5 replicates each) adult flies.
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15
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No associated institution

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