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Accession IconSRP170017

Ets1 suppresses atopic dermatitis by suppressing pathogenic T cell responses

Organism Icon Mus musculus
Sample Icon 6 Downloadable Samples
Technology Badge IconNextSeq 500

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Description
To identify the molecular mechanisms responsible for enhanced atopic dermatitis (AD) pathogenesis upon Ets1 deficiency in CD4+ T cells, we compared transcriptome profile between CD4+ T cells from littermate control (LMC) and Ets1?dLck mice at the peak of AD progression by performing RNA-seq. Overall design: Skin-draining lymph nodes near sites of inflammation under AD were excised from LMC and Ets1?dLck mice and prepared into single cell suspensions. CD4+ T cells were purified by CD4+ negative selection method.
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6
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