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Accession IconSRP158618

Using Gjd3-CreEGFP mice to examine atrioventricular node morphology and composition

Organism Icon Mus musculus
Sample Icon 1 Downloadable Sample
Technology Badge IconNextSeq 500

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Description
Gjd3-CreEGFP mice is a novel genetic tool to study the structural and molecular signatures of Atrioventricular Node (AVN) at a high resolution. Overall design: Focusing on the cardiac conduction system, we developed and rigorously characterized a geentic tool Gjd3-CreEGFP to perform in-depth analysis of AVN structure and composition. Utilizing this AVN-specific mouse model, we performed scRNA-Seq on neonatal Gjd3-CreEGFP mice to guide our single-cell atlas of the Atrio-ventricular conduction system (AVCS).
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