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Accession IconSRP158607

ATO treatment on mesenchymal stem cells (MSCs) interacting breast cancer cells

Organism Icon Homo sapiens
Sample Icon 6 Downloadable Samples
Technology Badge IconNextSeq 500

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Description
Based on next generation RNA-seq, we examed Arsenic trioxide treatment (ATO) effect on MSCs-interacting MCF7 cells in 3D cultures. We found gap junction protein Cx43 is dramatically downregulated after ATO treatment.. Overall design: human breast cancer cell line MCF-7 cells cocultured with mouse MSCs in 3D culture, with or without ATO treatment, are subject to NGS and then analyzed.
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6
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