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Accession IconSRP130653

Mutational signatures reveal the role of RAD52 in p53-independent p21 driven genomic instability

Organism Icon Homo sapiens
Sample Icon 12 Downloadable Samples
Technology Badge IconNextSeq 500

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Description
Genomic instability promotes evolution and heterogeneity of tumors. Unraveling its mechanistic basis is essential to design appropriate therapeutic strategies. In a recent study we reported an unexpected oncogenic property of p21WAF1/Cip1 showing that its chronic expression, in a p53-deficient environment, causes genomic instability by deregulating the replication licensing machinery.
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