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Accession IconSRP127247

ICAMs are not obligatory for functional immune synapses between naïve CD4 T cells and lymph node DCs

Organism Icon Mus musculus
Sample Icon 8 Downloadable Samples
Technology Badge IconNextSeq 500

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Description
The quantitative deep bulk MARS-seq analysis demonstrated that DCs from ICAM-1/2 double knockout (DKO) chimeric LNs display similar transcriptomes to those of WT DCs in both their resting and CD40 mAb activated states. Overall design: Transciptome analysis of activated and resting classical DCs from either WT or ICAM-1/2 DKO chimeric mice was performed. DC cells were isolated from popliteal lymph nodes and sorted according to the following markers: CD45, CD11c and MHC-II
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8
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