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Accession IconSRP127187

RNA deep sequencing analysis of glioma stem cells(GSCs) and non-GSCs

Organism Icon Homo sapiens
Sample Icon 11 Downloadable Samples
Technology Badge IconIllumina HiSeq 2500

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Description
To explore potential molecular mechanisms underlying the temporal process of DNA damage and repair in CSCs, we utilized deep RNA sequencing to analyze the expression of DNA damage and repair-associated genes at the transcriptome level. Our gene set analysis of CSCs and matched non-CSCs revealed a stemness-associated upward trend of global gene expression, particularly in NHEJ, mismatch excision repair (MMR) and HR pathways. Overall design: The RNA profiles of IN528, T3961, and T4121 CSCs and matched non-CSCs were generated by deep sequencing.
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11
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