github link
Accession IconSRP126583

A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection [Leicester non-progressor]

Organism Icon Homo sapiens
Sample Icon 129 Downloadable Samples
Technology Badge IconIllumina HiSeq 4000

Submitter Supplied Information

Description
Whole blood transcriptional signatures distinguishing patients with active tuberculosis from asymptomatic latently infected individuals have been described but, no consensus exists for the composition of optimal reduced gene sets as diagnostic biomarkers that also achieve discrimination from other diseases. Overall design: We undertook RNA Sequencing (RNA-Seq) of our earlier Berry et al. 2010 (GSE19444 and GSE19442) cohorts and additionally set up a prospective cohort study at Leicester (UK) in subject groups of incident TB and recent TB contacts, respectively. In the Leicester cohort, we performed systematic longitudinal sampling and clinical characterisation first, to validate our TB signature using RNA-Seq in a new and independent cohort of individuals with active TB and LTBI, and secondly to provide longitudinal data in a low TB incidence setting.
PubMed ID
Total Samples
138
Submitter’s Institution
No associated institution

Samples

Show of 0 Total Samples
Filter
Add/Remove
Accession Code
Title
Sex
Specimen part
Race
Subject
Processing Information
Additional Metadata
No rows found
Loading...