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Accession IconSRP117696

RNA-seq timecourse analysis during zebrafish heart looping morphogenesis

Organism Icon Danio rerio
Sample Icon 24 Downloadable Samples
Technology Badge IconIllumina HiSeq 2000

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During embryogenesis the heart forms as a linear tube that then undergoes multiple simultaneous morphogenetic events to obtain its mature shape. To understand the gene regulatory networks (GRNs) driving this phase of heart development, during which many congenital heart disease malformations likely arise, we conducted an RNA-seq timecourse in zebrafish from 30 hpf to 72 hpf and identified 5861 genes with altered expression. We clustered the genes by temporal expression pattern, identified transcription factor binding motifs enriched in each cluster, and generated a model GRN for the major gene batteries in heart morphogenesis.
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