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Accession IconSRP111135

Mechanisms of Cancer Resistance to Immunogenic Cytotoxicity

Organism Icon Homo sapiens
Sample Icon 4 Downloadable Samples
Technology Badge IconIllumina HiSeq 2000

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Description
The majority of cancer patients do not respond to immunotherapy. In order to systematically discover pathways promoting cancer cell resistance to effector immune cells, we generated immunity-resistant Head and Neck Squamous Cell Carcinoma cell lines. We utilized RNA-Seq to determine what are the genes and pathways that are significantly altered when cancer cells become resistant to effectors. Overall design: RNA-Seq was performed on four cell lines, including two biologic replicates of wildtype and immune-resistant PCI-13 cells. The two immune-resistant PCI-13 cell lines were generated separately using the same protocol described in the manuscript.
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4
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