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Accession IconSRP096788

Gene expression analysis of human spinal motor neurons (MN) differentiated from ALS patient derived iPSC

Organism Icon Homo sapiens
Sample Icon 4 Downloadable Samples
Technology Badge IconIllumina HiSeq 4000

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Description
iPSC derived from a patient heterozygous for the SOD1 E100G mutation were genome edited to homozygous wild type using the CRISPR-Cas9 system. Both disease and isogenic corrected iPSC were differentiated into spinal motor neurons that were ISL1+ and CHAT+. Gene expression changes in MN were analyzed by RNA-sequencing.
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