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Accession IconSRP095569

Gene expression profiling of cultured embryonic rat cortical neurons

Organism Icon Rattus norvegicus
Sample Icon 28 Downloadable Samples
Technology Badge IconIllumina HiSeq 2500

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Description
Embryonic CNS neurons can differentiate in culture and provide a model for maturation-related changes. A transcriptome profile over the course of maturation was perform to investigate the underlying molecular mechanism that drives maturation and its related changes such as developmental loss of intrinsic regenerative capacity. Overall design: Primary cortical neurons were excised from E18 rat embryos and were co-cultured with primary rat astrocytes from P0-2 rats. RNA were then extracted on day 1, 4, 8, 16, and 24 after plating.
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28
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