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Accession IconSRP092532

Gene Expression in Cx3cr1-GFP+ Cells in PS2APP Alzheimer''s Disease mice

Organism Icon Mus musculus
Sample Icon 15 Downloadable Samples
Technology Badge IconIllumina HiSeq 2500

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Description
This project defines the microglial gene expression profile in a transgenic mouse model of Alzheimer''s, compared to non-transgenic age-matched controls, at a time when amyloid pathology and microgliosis are rampant. Microglia were sorted live from one hemisphere of cerebral cortex, using GFP expressed from Cx3cr1 locus (mice have one intact copy of Cx3cr1). RNA was isolated from sorted microglia using RNeasy mini. Two groups, PS2APP and non-transgenic, with 9 mice/group, aged 14-15 months. The "SAMPLE_ID" sample characteristic is a sample identifier internal to Genentech. The ID of this project in Genentech''s ExpressionPlot database is PRJ0006715 Overall design: Gene expression in Cx3cr1::GFP+ sorted cells from cortex of wildtype or PS2APP at 14-15 months of age.
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15
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No associated institution

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