cFos-Sox9 Axis Reprograms Bone Marrow-derived Mesenchymal Stem Cells into Chondroblastic Osteosarcoma [RNA-seq]

The goal is to profile cFos binding sites in an p53 knockout mouse bone marrow-derived stem cells (mBMSCs). Overall design: Four single clones (clone2, 4, 8, 12) of p53 knockout (p53KO) mouse bone marrow-derived mesenchymal stem cells were transduced with retroviruses expressing either luciferase (Luc) or cFos cDNAs. RNA was extracted from cells and subject to RNAseq.

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He Y, Zhu W, Shin MH, Gary J, Liu C, Dubois W, Hoover SB, Jiang S, Marrogi E, Mock B, Simpson RM, Huang J