Genomic deletion of malic enzyme 2 confers collateral lethality in pancreas cancer

Comparison of malic enzyme 3 (ME3) depleted vs non-depleted xenograft tumors. ME3 is an isoform of ME2. Overall design: Sub-cutaneous tumors of nude mice injected with PATU-ishME3 (shRNA against ME3) and treated +/- Dox to knockdown ME3. 4 tumors off-dox and 2 tumors on-dox

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Dey P, Baddour J, Muller F, Wu CC, Wang H, Liao WT, Lan Z, Chen A, Gutschner T, Kang Y, Fleming J, Satani N, Zhao D, Achreja A, Yang L, Lee J, Chang E, Genovese G, Viale A, Ying H, Draetta G, Maitra A, Wang YA, Nagrath D, DePinho RA