Differential RNA-seq analysis comparing APC-defective and APC-restored SW480 colorectal cancer cells

Identify genes that are differentially regulated as a consequence of restoration of full-length functional APC in a colorectal cancer cell lines. Overall design: Examine mRNA expression level changes between SW480 (APC defective) and SW480+APC (SW480 cells with restored functional APC) cells, whilst accounting for any non-specific expression changes by comparison to SW480+control vector.

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King LE, Love CG, Sieber OM, Faux MC, Burgess AW