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Accession IconSRP065571

Sequential ligand-dependent Notch signaling activation regulates valve primordium formation and morphogenesis

Organism Icon Mus musculus
Sample Icon 16 Downloadable Samples
Technology Badge IconIllumina Genome Analyzer IIx

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Our studies identify a mechanism of signaling crosstalk during valve morphogenesis that sheds light on the origin of congenital heart defects associated with reduced Notch function. Overall design: Aortic and pulmonary cardiac valves were isolated by laser microdissection from WT and Jag1flox;Nkx2.5-Cre mouse embryos at stage E14.5, and their expression profile characterized by RNA-Seq.
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