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Accession IconSRP064271

Neutrophils oppose uterine epithelial carcinogenesis via debridement of hypoxic tumor cells

Organism Icon Mus musculus
Sample Icon 14 Downloadable Samples
Technology Badge IconIllumina HiSeq 2500

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Description
Our study demonstrates that neutrophils infiltrate early-stage PTEN-deficient uterine tumors and oppose tumor growth and malignant progression by inducing detachment and ultimately promoting cell death of tumor cells. This RNA-seq study examined the expression profiles of these uterine epithelial tumor cells in the presence versus absence of neutrophil infiltration. Overall design: Tumor cells from 4-week-old tumor-bearing neutrophil-sufficient versus -deficient mice were isolated by fluorescence activated cell sorting, RNA was isolated, and expression profiles were analyzed by deep sequencing.
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14
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