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Accession IconSRP062722

Mapping Replication Stress-Dependent Transcriptional Events Dependent on ATM or ATMIN by RNA-seq

Organism Icon Mus musculus
Sample Icon 32 Downloadable Samples
Technology Badge IconIllumina HiSeq 2000

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Description
The cellular response to replication stress requires the DNA-damage responsive kinase ATM and its co-factor ATMIN, however the roles of this signaling pathway following replication stress are unclear. RNA-seq and subsequent differential expression analyses were utilized to identify the functions of ATM and ATMIN in response to replication stress induced by Aphidcolin (APH). Overall design: Mouse Embryonic Fibroblasts (MEFs) deleted for ATM or ATMIN were treated with 1µM APH or DMSO as a control. Two different wild-type MEF cell lines (wtATM, wtATMIN) served as controls. RNA-seq was performed in duplicates, in a total of 32 samples, with an average of 31.1M aligned readsobtained per group,with 15.5M reads obtained per replicate.
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32
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