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Accession IconSRP059322

Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia

Organism Icon Homo sapiens
Sample Icon 21 Downloadable Samples
Technology Badge IconIllumina HiSeq 2500

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Description
We identified a novel recurrent genetic lesion in T-LGL. Mutations of the tumour suppressor gene TNFAIP3 causing amino-acid exchanges or protein truncations were seen in 3/39 cases (8%). Overall design: RNA sequencing (Illumina HiSeq 2500) of 5 index patients with paired tumor and non-tumor samples.
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21
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No associated institution

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