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Accession IconSRP050397

Defective removal of ribonucleotides from DNA promotes systemic autoimmunity

Organism Icon Homo sapiens
Sample Icon 15 Downloadable Samples
Technology Badge IconIllumina HiSeq 2500

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Description
Constitutive low level DNA damage in RNASEH2 deficiency is linked to innate immune activation. Hierarchical clustering of over 16000 transcripts revealed remarkably similar profiles in patients with lupus erythematosus and patients with AGS with up-regulation of genes involved in DNA damage signaling and type I-IFN signaling. Overall design: Comparison of transcriptional profiles of native RNASEH2-deficient patient fibroblasts with wild type cells.
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15
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