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Accession IconSRP048605

Human induced pluripotent stem cells Transcriptome or Gene expression

Organism Icon Homo sapiens
Sample Icon 3 Downloadable Samples
Technology Badge IconIllumina HiSeq 2500

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We show that ERR? overexpression in ß-like-cells differentiated from human iPSCs enhances genes involved in mitochondrial metabolism, resulting in transformation of these cells into metabolically functional ß-cells that can ameliorate STZ-induced hyperglycemia in NOD-SCID mice. These results suggest that ERR? signaling is essential for the metabolic maturation of ß-like-cells and thus represents a novel therapeutic target in the treatment of diabetes.
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