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Accession IconSRP044124

BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein

Organism Icon Mus musculus
Sample Icon 8 Downloadable Samples
Technology Badge IconIllumina Genome Analyzer

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Description
Coordinated BCR-ABL1 kinase-dependent and -independent mechanisms convert p27 from a nuclear tumor suppressor to a cytoplasmic oncogene. Persistence of oncogenic p27 functions despite effective inhibition of BCR-ABL1 may contribute to resistance to tyrosine kinase inhibitors. Overall design: BCR-ABL1 induced p27 versus knockout, controlling with Empty vector p27 versus knock out
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8
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